Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus

Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus

Researchers from the GIGA Cellular and Molecular Immunology Laboratory (led by Nathalie Jacobs) and ULB’s Pharmacotherapy and Pharmaceutical Pharmacy Department (led by David Vermijlen) have investigated unconventional T lymphocytes cells expressing a receptor composed of γ and δ chains, in the specific case of human papillomavirus-induced (HPV) cervical cancer.

Of all tumor-infiltrating leukocytes, T cells bearing γδ T cell receptors have been associated with the most favorable prognosis. However, we show here, in a mouse model of carcinogenesis induced by human papillomavirus (HPV)-oncoproteins, that γδ T cells promoted the development of HPV-induced lesions.

Indeed, HPV-oncoprotein expression induced an infiltration of γδ T cells producing IL-17A, a proangiogenic cytokine, and a decreased density of anti-tumor Vγ5+ γδ T subsets. Supporting the clinical relevance of our observations, IL-17A+ γδ T cells were detected in human cervical cancer, where HPV-oncoproteins are highly expressed, but not in less advanced cervical lesions.

These results support the notion that viral oncoproteins can induce a switch from antitumoral to pro-tumoral γδ T subsets in solid tumors.

Related articles

A gammaherpesvirus infection can protect against allergic asthma

Bénédicte Machiels and Mickaël Dourcy, under the direction of Laurent Gillet (Laboratory of Immunology-Vaccinology (FARAH)), and their colleagues from ULiège and UGent, investigated the imprinting left by the herpesviruses, and more specifically gammaherpesviruses, on the immune system of their host.  In fact, gammaherpesviruses (including the Epstein-Barr virus, responsible for infectious mononucleosis in humans) are very common viruses having co-evolved with

Read more
A gammaherpesvirus infection can protect against allergic asthma

2017 Annual Meeting of the « Structure et Fonctions des Macromolécules Biologique Bioinformatique et Modélisation » Graduate school

On 10th November 2017, the 11th Annual Meeting of the Graduate school “Structure et Fonctions des Macromolécules Biologiques, Bioinformatique et Modélisation” (SFMBBM) is taking place at the University of Liège. This year’s meeting aims to represent the spectrum of biological macromolecules, from nucleic acids to proteins and their interactions, and from their physiological function to

Read more
2017 Annual Meeting of the « Structure et Fonctions des Macromolécules Biologique Bioinformatique et Modélisation » Graduate school

Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus

Researchers from the GIGA Cellular and Molecular Immunology Laboratory (led by Nathalie Jacobs) and ULB’s Pharmacotherapy and Pharmaceutical Pharmacy Department (led by David Vermijlen) have investigated unconventional T lymphocytes cells expressing a receptor composed of γ and δ chains, in the specific case of human papillomavirus-induced (HPV) cervical cancer. Of all tumor-infiltrating leukocytes, T cells bearing

Read more
Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus