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Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus
Researchers from the GIGA Cellular and Molecular Immunology Laboratory (led by Nathalie Jacobs) and ULB’s Pharmacotherapy and Pharmaceutical Pharmacy Department (led by David Vermijlen) have investigated unconventional T lymphocytes cells expressing a receptor composed of γ and δ chains, in the specific case of human papillomavirus-induced (HPV) cervical cancer.
Of all tumor-infiltrating leukocytes, T cells bearing γδ T cell receptors have been associated with the most favorable prognosis. However, we show here, in a mouse model of carcinogenesis induced by human papillomavirus (HPV)-oncoproteins, that γδ T cells promoted the development of HPV-induced lesions.
Indeed, HPV-oncoprotein expression induced an infiltration of γδ T cells producing IL-17A, a proangiogenic cytokine, and a decreased density of anti-tumor Vγ5+ γδ T subsets. Supporting the clinical relevance of our observations, IL-17A+ γδ T cells were detected in human cervical cancer, where HPV-oncoproteins are highly expressed, but not in less advanced cervical lesions.
These results support the notion that viral oncoproteins can induce a switch from antitumoral to pro-tumoral γδ T subsets in solid tumors.
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by