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Gamma-Delta T lymphocytes, promote cervical cancer caused by the papillomavirus
Researchers from the GIGA Cellular and Molecular Immunology Laboratory (led by Nathalie Jacobs) and ULB’s Pharmacotherapy and Pharmaceutical Pharmacy Department (led by David Vermijlen) have investigated unconventional T lymphocytes cells expressing a receptor composed of γ and δ chains, in the specific case of human papillomavirus-induced (HPV) cervical cancer.
Of all tumor-infiltrating leukocytes, T cells bearing γδ T cell receptors have been associated with the most favorable prognosis. However, we show here, in a mouse model of carcinogenesis induced by human papillomavirus (HPV)-oncoproteins, that γδ T cells promoted the development of HPV-induced lesions.
Indeed, HPV-oncoprotein expression induced an infiltration of γδ T cells producing IL-17A, a proangiogenic cytokine, and a decreased density of anti-tumor Vγ5+ γδ T subsets. Supporting the clinical relevance of our observations, IL-17A+ γδ T cells were detected in human cervical cancer, where HPV-oncoproteins are highly expressed, but not in less advanced cervical lesions.
These results support the notion that viral oncoproteins can induce a switch from antitumoral to pro-tumoral γδ T subsets in solid tumors.
Liège (Belgium), 21st January 2019. PDC*line Pharma is delighted to announce, that the company is now accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for the Quality Control and Release activities of its anticancer agent PDC*lung, intended for the treatment of patients with lung cancer. PDC*line Pharma is developing a new
The Medical Simulation Center of the University of Liège organizes its first congress in Health Simulation: “Towards evidence-based simulation”. Event will be held on Thursday, March 28th, 2019 in the faculty of medicine amphitheatres of Liège University, located on Sart-Tilman campus. Several themes will be discussed: Evidence-based Innovations and advances in simulation Medical education –
The Clinical Sciences Department of the Medicine Faculty of the University of Liège organizes from the academic year 2018-2019 a University Certificate in clinical trials. More information is available in this folder