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A new LC-MS method for GFR determination: an important tool for the diagnosis of chronic kidney disease
In order to assess the renal function, EMA guidelines recommends to use a method accurately measuring glomerular filtration rate (GFR) based on exogenous markers.
In this context, a research team from the Clinical Chemistry Department of the University Hospital of Liège (CHU de Liège), in collaboration with the Nephrology Service, has developed a new LC-MS/MS method to determine GFR through the quantification of iohexol clearance in serum. This contrast agent possesses all features of a good GFR marker and is readily available. Its detection combined LC-MS/MS with selected reaction monitoring (SRM), to ensure the specificity of the method.
This new technique offers an increased accuracy, a better selectivity, and was successfully validated from an analytical point of view. This original approach is ready to be used in routine practice and clinical research.
The results have been published in the “Clinica Chimica Acta”
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by