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A new model for understanding gene transcription
Researchers from the ULg (Franck Dequiedt’s Laboratory, GIGA-R) in collaboration with ULB, KUL and American researchers have recently published findings in the journal Nature Structural & Molecular Biology indicating that control of gene expression by mammalian transcription factors may follow a more complex scheme than previously anticipated, by regulating all the steps of the gene expression (integrating mRNA synthesis and degradation).
With this discovery, the researchers invite to review the current understanding of the eukaryotic gene regulation and this opens a wide field of new therapeutic perspectives in medical research since transcription factors are involved in the development of many diseases such as certain cancers.
Transcription factors play a fundamental role in gene regulation. However, the current model confines these proteins in the early stages of gene expression, in the synthesis of messenger RNA (transcription step). Until now, the family of ERG proteins (E-26 related gene) were considered prototypical transcription factors controlling the transcription of genes involved in fundamental processes such as proliferation, differentiation or cellular death. In a publication in Nature Structural & Molecular Biology, ULg researchers in collaboration with ULB, KUL and US (Harvard, Dana-Farber Cancer Institute, Rockefeller University) researchers have shown that ERG-factors are involved not only in the synthesis of messenger RNA (mRNA) in the nucleus, but also during its degradation in the cytoplasm. The researchers specifically identified the molecular mechanisms associated with this new feature: the ERG factors bind to mRNA via specialized proteins (RBP: RNA-binding proteins) and then recruit the CCR4-NOT complex, a multiprotein complex ensuring deadenylation of mRNAs, the first stage of the degradation process in eukaryotes. The researchers also provided a biological context to their observations by showing that the coordinated control of the synthesis and degradation of specific mRNAs by ERG was essential to the completion of the cell mitosis process (nuclear division). These findings raise the question on the role of transcription factors since it shows that these proteins are also involved in the late stages of gene expression process. More broadly, these findings suggest that accompanying the mRNAs from their “birth” to their “death”, transcription factors play a leading role, allowing the cell to effectively coordinate all stages of gene expression.
Source: The transcription factor ERG recruits CCR4-NOT to control mRNA decay and mitotic progression.Published online on 06.06.2016 on the Nature Structural & Molecular Biology website, DOI 10.1038/nsmb.3243
Liège (Belgium), 21st January 2019. PDC*line Pharma is delighted to announce, that the company is now accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for the Quality Control and Release activities of its anticancer agent PDC*lung, intended for the treatment of patients with lung cancer. PDC*line Pharma is developing a new
The Medical Simulation Center of the University of Liège organizes its first congress in Health Simulation: “Towards evidence-based simulation”. Event will be held on Thursday, March 28th, 2019 in the faculty of medicine amphitheatres of Liège University, located on Sart-Tilman campus. Several themes will be discussed: Evidence-based Innovations and advances in simulation Medical education –
The Clinical Sciences Department of the Medicine Faculty of the University of Liège organizes from the academic year 2018-2019 a University Certificate in clinical trials. More information is available in this folder