A new unit for the CHU Liège Toxicology Department to better serve the pharma sector

A new unit for the CHU Liège Toxicology Department to better serve the pharma sector

ATC is a contract research organisation (CRO) with its facilities based within the CHU Liege. Its flexibility and multidisciplinary expertise, its access to patients via its privileged contacts with CHU medical departments and its links to ULg research centres are key factors determining its consistent success over the last third of a century.

As of 1 January 2017, the services offered to customers have taken on a new dimension.

ATC was historically made up of two units: the Pre-Clinical and Analytic (PCA) Unit specialised in the bio-analysis of physiologically active substances and the conduct of pre-clinical studies (in vitro & in vivo); and the Clinical Pharmacology Unit, specialised in carrying out clinical trials (Phase 0, I, IIa or Early Phase).

The PCA unit has now become part of the CHU Liège Toxicology Department (itself part of the Unilab Lg), headed by Prof. Corinne Charlier.   “Over time, these two departments have come to develop very similar activities, using the same high-performance technologies and both having high-qualified staff able to carry out tasks in this field in compliance with international quality standards. The synergies were obvious”, explained Prof. Charlier.

The PCA Unit is thus changing its name, and will henceforth by known as the GLP Unit for Pre-Clinical and Toxicological Analyses and Evaluations (GLP-AEPT). As indicated by its name, its mission to provide services complying with “good laboratory practice” (GLP) will be maintained and even strengthened. The new unit’s technical facilities reflect this mission: 7 coupled liquid chromatography/mass spectrometry systems, including 4 ultra-high-pressure liquid chromatography systems, 4 coupled gas chromatography/mass spectrometry systems, 2 plasma torches, and many other systems.

“The existing intense collaboration between the ATC’s Clinical Pharmacology Unit, specialised in Phase I clinical trials, and the new GLP AEPT will be strengthened by this restructuring”, said Dr. Patrice Chiap.

Moreover, integrating this unit into the Toxicology Department means that customers can now be offered a very flexible service, allowing tight deadlines, the possibility of very varied analyses, and wide-ranging expertise in the field of pharmacological, pharmacokinetic and toxicological evaluations. The scientific team is made up of pharmacists, bio-pharmacists, chemists and engineers. Each project is supervised by a study director working in close collaboration with the customer to achieve a tailor-made solution covering a wide range of services.

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