Clinical imaging

Together, the CHU and the GIGA have a vast expertise in clinical imaging techniques, individually or combined in a multimodal functional imaging approach.

Picture3Magnetic resonance imaging (MRI) scanners use strong magnetic fields and radio-waves to visualize detailed-internal structures. Images are obtained in vivo with very high spatial and temporal resolution and good contrast for brain and soft tissues. MRI can be used in a wide variety of applications including anatomical, functional (fMRI) and molecular imaging for medical diagnosis, staging of disease and for follow-up without exposure to ionizing radiation.

Equipment: two 3T Siemens Allegra with parallel imaging capabilities (8-channel receive coil), one 1.5T Siemens Symphony and two 1.5 Siemens Aera Scanners.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

gemini tf16Positron Emission Tomography (PET) has the sensitivity to visualize at picomolar level molecular processes in 3D and in a volume and target-depth independent manner. As a stand-alone device or combined with a CT scanner (PET-CT), it allows a wide range of clinical and experimental applications:

  • Dynamic brain imaging (arterial blood sampling):
    • Concentration analysis of targeted analytes
    • Dynamic PET with tracer kinetic modeling techniques
  • Static brain imaging with 18F radiopharmaceuticals
  • Whole-body imaging for dosimetry:
    • Collection of quantitative and dynamic biodistribution data
    • Detailed drug occupancy studies
  • Whole-body imaging for metabolic evaluation, receptor or gene expression, with or without full diagnostic contrast-enhanced CT imaging

Equipment: PET scanner Siemens HR+, PET/CT Philips Gemini TF16 & Philips Gemini TF Big Bore (fully fitted for RT Planning)

In addition, we have:

  • Expertise in the development of new radioligand (for more info, click here)
  • Marketing Authorization Application to produce 18F-FDG (#BE241132)
  • Marketing Authorization Application to produce 68GA labelled compound
  • Certification to synthesize radiolabeled registered and experimental drugs
  • Authorization to conduct research programs with clinically validated 18F-FDG or original radiotracers
  • Expertise in experimental design, data collection, correction and modeling for kinetic analysis

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Picture4SPECT is a nuclear medicine tomographic imaging technique, which uses radiopharmaceutical emitting gamma rays. Similar to PET, it can be combined with a computed tomography (CT), a cross-sectional technique that yields structural and anatomical high-resolution 3D images.

Equipment: 2 SPECT-CT Siemens Symbia T6, 1 SPECT Siemens E-Cam.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

BrightSpeedElite-281x300A computerized tomography (CT) scan combines a series of X-ray images taken from different angles and uses computer processing to create cross-sectional images, or slices, of bones, blood vessels and soft tissues inside the body.

Equipment: 2 GE Brightspeed Elite scanners, 2 Siemens Somaton Emotion scanners, 1 Siemens Somaton Definition scanner.

Motion analysis

We can offer you a fully integrated analysis of the subject including spatio-temporal parameters (step frequency, step length, velocity, single and double support time…) and kinematics parameters (angular range of motion, velocity, ground reaction forces, muscles activity). Tests are performed in a 27 meters long-room (ensuring that subjects reach stabilized gait) in which the equipment can be used simultaneously and be synchronized on demand.

 

Force plates measure the ground reaction forces generated by a body standing on or moving across them, allowing investigators to quantify balance, gait and other biomechanical parameters.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

 

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Electromyography (EMG) allows to evaluate muscles activity and is composed of several sensors (one for each studied muscle) placed at the surface of the skin. EMG is mainly used as a diagnostic tool to identify neuromuscular diseases and can be applied to study the effect of a given treatment (drug, rehabilitation program), ergonomics…

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

The Locometrix® accelerometer device provides a quick and informative walking test in the context of defining a diagnosis. The software automatically calculates 6 common dynamic characteristics of walking: symmetry, regularity, force, frequency, pathogenic shock waves and frontal instability. The system provides reference databases, allowing the user to interpret the test results in a matter of minutes. In practice, an accelerometer, fixed by a belt on the lumbar region, registers all movements of the center of gravity during walking, running or other athletic movements.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

 

Codamotion® is a 3D motion capture system, which tracks and analyzes 3D movement. This system is very versatile and can provide a large variety of information including the common gait parameters (stride frequency, gait velocity…) as well as kinematic information (ankle, knee, hip angles).

A Codamotion® system is ideal for analyzing all scales of human body. Small scales details of hand, face, feet and spine can be captured together with large-scale whole-body movements. Critically the active maker technology used in Codamotion® systems produces real time data. Less than 1ms elapses between a measurement and its availability for processing and display.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

With a set of range laser scanners, engineers at ULg have developed a new non-intrusive feet tracker system called GAIMS (for “Gait Analysis Imaging System”, “Gait Measuring System »). The observed person does not need to carry any sensor or marker, has not to wear special clothes, and is not restricted to walk on a small area such as a treadmill.

This system can detect the real time position of each foot during different types of simple walking tasks. It enables the calculation of different gait parameters (global or single foot walking speed, single and double limb support times, base of support width, number of missteps…).

These characteristics can be used for the diagnostic of various diseases and for the longitudinal follow-up of patients with walking impairments.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Safety (Phase I)

Patient administration:

  • Centralized clinical unit with 30 equipped hospital beds
  • Experience in running different study types and trial design
  • Different types of drugs like NCE and NBE
  • Database of more than 1700 healthy and reliable volunteers
  • Privileged access to medical and technical expertise of CHU and ULg (such as Cyclotron, GIGA, CIP, Sleep Center, Pain clinic…)

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We offer you a professional and scientific support to conduct clinical trials and the decision making processes during the early phases of the development of new molecules. This includes clinical pharmacology trials giving an insight into a drug candidate’s safety, tolerability, pharmacokinetics and pharmacodynamics.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.


Efficacy/tolerability clinical trials (Phase IIa to III)

The CHU de Liège has in-depth expertise in various therapeutic fields.

Thanks to our unique regional location, we have a quick access to a large and available network of all kinds of patients.

We can help you with:

  • Indication selection
  • Clinical trial design
  • Synopsis redaction
  • Ethical committee presentation
  • Clinical trial performance
  • Reporting
  • Efficacy and safety tests
  • Biomarkers
  • Hormonal modifications
  • Metabolism (PK, PD)
  • Biostatistics

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Bio-analysis

  • Standard bio-analysis: certification for more than 550 tests, 17025 and 15189 ISO standards and BELAC accreditation
  • Development of personalized drug monitoring
  • Determination of IMP, metabolites and drug residues in different biological matrices
  • PK, PD and immunogenicity testing

For more information, click here.

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In addition, we manage API bulk reception, drug formulation and release. For more information, click here.

For your cell therapy requirements, you can click here to find out more about our CHU-LTCG facility on ATMP production in GMP conditions.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.