Drug synthesis

Logo_Logo-autres_CIRMThe CIRM has developed a great expertise in the design, synthesis, purification and structure elucidation of synthetic and natural pharmaceutical molecules such as new drug substances or new pharmacological tools.

We are accredited by the FAMHP for the analysis of plant materials, herbal medicines and drug substances (GMP label). We are part of the European network of Official Medicines Control Laboratories (OMCL), led by the European Department of the Quality of medicines (EDQM).

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

 

Radiopharmaceutical development & production

Logo_Logo-autres_CRC_2Our team at CRC constantly develops faster, cheaper and safer techniques to prepare PET tracers. As a result, more convenient methods to introduce 18F on organic compounds were developed and patented.  Thanks to these technical developments, we are now able to produce multiple high-quality 18F based tracers suitable for clinical studies (GMP facilities). Some recent molecular imaging technologies require more elaborated radiolabeled compounds (e.g. peptides, proteins, oligonucleotides, lipids…) facing significant stability issues and side reactions. To tackle this increasing problem, we have developed a library of small 18F labelled compounds (prosthetic groups), which can be easily conjugated to biomolecules specific to the targeted biological process.

See here below for the different services we can provide:

Formulation

Picture_FormulationThe CIRM has expertise in small and large molecule formulation development. It is the first academic department in Europe that has obtained the GMP label. Furthermore, we obtained Federal Agency for Medicines and Health Products agreement since 1997. Our in-depth knowledge and in-house equipment allow us to develop and design a wide variety of dosage forms and drug delivery systems.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Analytical Platform

Being the first academic department in Europe with a GMP label, the CIRM can provide professional expertise with highly-equipped laboratories to support the development, robust optimization and validation of analytical and bioanalytical methods following ICH/FDA recommendations, such as:

Analytical platform