Potassium channel modulators

The new compounds based on disubstituted anilines, by opening potassium channels, can be used for the treatment of vasospastic disorders (i.e. subarachnoid hemorrhage and migraine), of various diseases of the central nervous system (i.e. epilepsy, ischemia and neurodegenerative diseases) as well as pain treatment.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Novel pharmaceutical formulations

Researchers at ULg have a broad expertise in the development of novel pharmaceutical formulations to improve the solubility and the bioavailability of compounds and to facilitate drug delivery to brain cells.

To test these new formulations, they have also developed a cellular blood brain barrier model using immortalized human cerebral microvascular endothelial cells.

For more information, click here.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

EFHC1 in juvenile myoclonic epilepsy

Mutations in the EFHC1 gene have been found in several patients suffering from juvenile myoclonic epilepsy (JME). Researchers at GIGA have shown that EFHC1 loss of function disrupts cell division and induces apoptosis in cell culture.

Using ex vivo electroporation, they observed a dramatic decrease of radial migration because both division of cortical progenitors and locomotion of postmitotic neurons are impaired in the absence of the protein. Therefore, they propose that abnormal neuronal migration during development could lead to abnormal brain circuitry that, in turn, will produce JME.

Their goal is now to study the effect of EFHC1 and of its mutated forms on neocortical development and, subsequently, to study the functional consequences of the migratory deficits induced by EFHC1 loss of function.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

In silico modeling

Researchers at GIGA have developed simple mathematical models to investigate several theories of migration of neuroblasts through the rostral migratory stream proposed in the literature, including chemo-attraction, chemorepulsion, general inhibition and the presence of a migration-inducing protein. Apart from the general inhibition model, all the models were able to provide results in good qualitative correspondence with the experimental observations.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!