Regenerative therapy

Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI).

Researchers at GIGA have investigated the impact of pure populations of mesenchymal stem cells (MSCs) and neural crest stem cells (NCSCs) isolated from adult bone marrow in a mouse model of spinal cord injury.

They observed that both cell types induced motor recovery in mice, and modified the inflammatory reaction in the lesion site.

Their preliminary results suggest that both cell types have beneficial effects in experimental SCI.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

 

Role of elongator complex

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the brain and spinal cord. The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease whereby the immune system malfunction destroys myelin. Among others, one strategy to treat MS is to stimulate the recruitment and the activation of resident oligodendrocyte precursor cells (OPCs) to differentiate them into functional myelinating cells.

In this context, researchers at GIGA are studying the role of the Elongator complex in the adult CNS demyelination and demyelination processes.

Their preliminary obtained results suggest that Elongator could play a role in the differentiation of OPCs and act as a negative regulator of the demyelination.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Novel pharmaceutical formulations

Researchers at ULg have a broad expertise in the development of novel pharmaceutical formulations to improve the solubility and the bioavailability of compounds and to facilitate drug delivery to brain cells.

To test these new formulations, they have also developed a cellular blood brain barrier model using immortalized human cerebral microvascular endothelial cells.

For more information, click here.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

In silico modeling

Researchers at GIGA have developed simple mathematical models to investigate several theories of migration of neuroblasts through the rostral migratory stream proposed in the literature, including chemo-attraction, chemorepulsion, general inhibition and the presence of a migration-inducing protein. Apart from the general inhibition model, all the models were able to provide results in good qualitative correspondence with the experimental observations.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!