Hematology

VOC measurements

One of the research teams at ULg is leading the field of volatile organic compounds (VOC) measurements in all kinds of biological matrices.

The laboratory is equipped with state-of-the-art Separation Science tools and offers all possible sample collection and introduction devices (TD, SPME, mSBSE, DHS, SHS, SPE…), each being automated.

The analysis of VOCs in patient exhalation for the diagnosis is performed using high-resolution spectrometry (GC×GC-HRTOFMS) that makes all chromatographic separation efficient and mass spectrometric measurements accurate and precise for both target and unknown characterization and measurements

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Thrombotic diseases

Clinical management of cardiovascular thrombotic diseases and participation in several international studies in acute coronary syndromes.

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Cardio-oncology

At Belgian level, CHU de Liège coordinates the European multicenter registry which is in charge to evaluate current practices in terms of diagnosis and management of cardiac toxicity of breast cancer treatments (COT registry: EACVI/HFA Cardiac Oncology Toxicity Registry in Breast Cancer: EURObservational Research Program of the European Society of Cardiology).

In addition, our team evaluates new cardiac toxicity biomarkers (mRNA, BNP, ST2, Troponine, etc) in breast cancer as well as multi-modality imaging evaluations of cardiovascular complications of radiotherapy in adult.

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Valvular Heart Disease

Our team has been working for 10 years on valvular heart disease and highlighted several factors of poor clinical outcome through biomarker assay  (BNP, ST2, etc), the use of advanced echocardiographic techniques (study of myocardial deformation, ultrasound effort, etc) and the assessment of functional capacity.

CHU de Liège has created the ‘Heart Valve Clinic’, regrouping a multidisciplinary team of cardiologists, nurses, radiologists, anaesthesiologists and surgeons:

  • Proficient in diagnosing and treating all cardiac valve syndromes and disorders. This involves sophisticated cardiac valve symptoms recognition, diagnostic techniques such as three-dimensional echocardiography, cardiac magnetic resonance, cardiac CT and cardiac catheterization
  • Providing help in optimizing and monitoring medical treatment
  • Assisting the general cardiologists for clinical decision-making
  • Determining the correct timing and type of intervention
  • Referring the patient to the most suitable surgeon
  • Assessing results after intervention
  • Informing patients to motivate them to follow their prescribed medications and be alert for signs indicating a worsening of their disease

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Abdominal aortic aneurysms

A study carried out by the teams at CHU de Liège revealed that recourse to the PET-CT medical imaging method was efficient in detecting aneurysms that are likely to rupture.

They are currently exploring if a correlation between PET-CT images and the presence of specific molecules in the samples of aortic wall taken from the areas of high metabolic activity in the aneurysm can be detected.

With the collaboration of the Karolinska Institute, the CHU de Liège has launched a systematic screening campaign for abdominal aortic aneurysm, which is funded by Aneurysmal Pathology Foundation (APF).

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Radiotracers

GIGA researchers have developed the 18F-FB-mini-PEG-E[c(RGDyK)](2), 18F-FPRGD2, a radiopharmaceutical targeting the integrin αvβ3, a transmembrane heterodimeric receptor regulating cell interaction with the extracellular matrix (ECM). The interaction site of integrin αvβ3 with ECM is a tripeptide sequence arginine-glycine-aspartic acid (RGD) present in a wide range of ECM molecules including fibronectin, fibrinogen, von Willebrand factor, thrombospondin, vitronectin, tenascin, osteopontin and bone sialoprotein.

They have recently reported the osteoarticular uptake of 18F-FPRGD2 in a large cohort of 61 patients primarily studied for oncologic purposes. The results were the first showing the systematic analysis 18F-FPRGD2 uptake in the musculoskeletal system. Their data clearly identified a homogeneous binding of the 18F-FPRGD2 within structures that anatomically correspond to the cartilage surrounding the femoral head of an osteoarthritic hip. They have observed similar global fixation of the tracer on the entire degenerated disc.

Highlighting the role of integrins in osteoarthritis development opens the door to osteoarthritis diagnosis using in vivo non-invasive and quantitative imaging technology.

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Patient diagnosis, treatment & follow-up

  • Histological changes: development of specific MRI sequences to demonstrate histological changes associated with spinal cord injury, including degeneration of white matter tracts. These new quantitative imaging techniques allow to assess the degree of damage and the beneficial effects of spinal cord repair strategies.
  • Measure axonal loss in patients with a corticospinal tract impairment, based on transcranial magnetic stimulation. This technique provides accurate data to identify patients in need of a more aggressive therapy and will potentially be a reliable tool to measure the secondary progression of the disability.
  • GAIMS project: collaborative project between ULg and CHU to develop a new gait analysis system well suited for the clinical routine. It provides a reference database with the gait characteristics of many MS patients and healthy people. Related to the disease progression, gait impairment characteristics allow to define an objective and quantitative score for the longitudinal follow-up of MS patients during their treatment and rehabilitation programs

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Patient diagnosis, treatment & follow-up

The CHU de Liège has created a Science Alliance called MoVeRe bringing together scientists involved in the study and care of patients with Parkinson’s disease and other movement disorders. This group is specialized in:

  • Diagnostic consultations of patients with cognitive impairment
  • Neuropsychological characterization of cognitive difficulties
  • Analysis of the sub-thalamic nucleus at rest and during specific tasks
  • Assessment of quantitative gait features in a clinical setting
  • Integrating clinical scales, brain imaging (by MRI, PET or EEG), motion sensors and molecular information
  • Evaluating treatments for cognitive difficulties
  • Implementing and evaluating cognitive rehabilitation methods
  • Performing pharmacological and non-pharmacological therapeutic trials
  • Transcranial Magnetic Stimulation (TMS)

MoVeRe has access to a large clinical database of more than 1.000 patients with Parkinson’s disease and abnormal movement patterns.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Patient diagnosis, treatment & follow-up

  • Discriminating prognostic classification based on clinical and biological analysis
  • Novel magnetic resonance imaging sequences to predict the topography of tumor recurrence
  • Revisiting the structural and functional anatomy of the Sylvian fissure (lateral sulcus) which includes the white matter pathways for surgery of the insula in case of glioblastoma

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