Regenerative therapy

Stem cells from adult tissues were considered for a long time as promising tools for regenerative therapy of neurological diseases, including spinal cord injuries (SCI). Researchers at GIGA have investigated the impact of pure populations of mesenchymal stem cells (MSCs) and neural crest stem cells (NCSCs) isolated from adult bone marrow in a mouse model […]

Role of elongator complex

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the brain and spinal cord. The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease whereby the immune system malfunction destroys myelin. Among others, one strategy to treat MS is to stimulate the recruitment and the activation of resident oligodendrocyte precursor cells (OPCs) to differentiate them into […]

New TP receptor antagonists

Researchers at CIRM have synthesized and evaluated new series of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor (TP receptor) antagonists. Based on functional pharmacological test, several compounds were found to be as potent as the 2-arylamino-5-nitrobenzenesulfonylurea reference compound BM-573, supporting the view that the bio-isosteric replacement of the nitro group by a cyano group was tolerated. […]