Diagnostic method for osteoarthritis

Diagnostic method for osteoarthritis

A new method has been developed for the early detection and monitoring of osteoarthritis progression.

This highly reproductible method refers to LC-MS/MS technology and to the simultaneous analyses of complement C3f and vibronectin fragments in fluid samples.


Thermoformating apparatus for continuous production of solid oral dosage forms

Thermoformating apparatus for continuous production of solid oral dosage forms

Researchers at ULiège have created a new equipment for continuous production of solid oral dosage forms. Build to be used downstream of standard hot melt extruder, the thermoformating apparatus enables a full continuous production of final drug which fulfill the requirements of the European Pharmacopeia.


Easy-P

Easy-P

The Nephrology Department of ULiège  has designed “EASY-P”, a Portable user-friendly device allowing a simplified measure of daily diuresis without collecting urine.


Breathprint

Breathprint

Researchers at ULiège have identified a signature of 7 Volatile Organic Compounds (VOCs) able to determine the asthma phenotype in an easier, faster more accurate and more cost-effective way than usual diagnostic methods.


Continuous-flow process for methylphenidate hydrochloride preparation

Continuous-flow process for methylphenidate hydrochloride preparation

The patented technology consists in an alternate more cost effective process for the preparation of the active pharmaceutical ingredient threo-methylphenidate hydrochloride, a central nervous system stimulant.

Specific process conditions were developed to meet the specific requirements of continuous-flow reactors.

This work fits in the actual context of developing efficient continuous-flow processes for the continuous manufacturing of active pharmaceutical ingredients.


Probiotic bacteria: new species

Probiotic bacteria: new species

Two new patented Bifidobacterium species, B. crudilactis sp. nov. (100 strains) and B. mongoliense sp. nov. (20 strains) have been isolated from raw milk and raw milk cheese.

Those species can easily be integrated into various manufacturing processes and stabilized in food and fermented products.

Potential for immunomodulatory effects and good resistance to biological barriers.


Innovative chitosan-based biomimetic scaffold for wound repair and tissue engineering

Innovative chitosan-based biomimetic scaffold for wound repair and tissue engineering

Our researchers at the ULiège have developed an innovative chitosan-based scaffold for wound repair and tissue engineering. This new scaffold-type has unique structural properties that stimulate the healing process and improve of the overall quality of the repaired tissue through a more adequate revascularization, re-epithelialization and remodeling of the granulation tissue. Easy-to-handle, and large potential for re-modelling.


Scaffold for the cultivation of cartilage-forming cells

Scaffold for the cultivation of cartilage-forming cells

The present invention relies upon a new scaffold based on chitosan/alginate hydrogel beads, for the cultivation of cartilage-forming cells.

The combination of chitosan and alginate might improve traumatic or degenerative cartilage lesion treatment. Compared to other types of cellularised beads, the present beads can be prepared in a more reproducible way: stabilization of the chondrocytes’ phenotype, while ensuring an optimal space distribution of cells in the host tissue or organ.

 


New Synthetic Antidote of Heparin

New Synthetic Antidote of Heparin

This synthetic hemocompatible polymer is an elegant high-quality alternative to protamine-sulphate (PS) for the rapid and efficient neutralization of heparin (non fractionated and fractionated) in complex biological media such as human plasma.

The synthetic nature of this heparin antidote allows to overcome most of the challenges faced by PS, ie like residues, purity, supply, and consistency while maintaining a similar efficacy and onset of action.


A new target to optimize anti-EGFR therapies

A new target to optimize anti-EGFR therapies

Our researchers at ULiège have established an unexpected functional link between MT4-MMP (MMP-17) and EGFR pathway that allows optimizing treatment and prediction of the responsiveness to anti-EGFR in cancer therapy.