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Researchers at ULg identify a new role of osteopontin in DNA repair and its impact on human glioblastoma radiosensitivity
A team of scientists directed by Prof. A. Bellahcène and Prof. V. Castronovo, researchers at ULg’s GIGA research centre, has reported for the first time the impact of osteopontin (OPN) silencing on the radiosensitivity of glioblastoma (GBM) cells through interference with DNA double-strand repair machinery (Data published in Oncotarget).
GBM represents the most aggressive and common solid human brain tumor. ULg researchers have recently demonstrated the importance of osteopontin in the acquisition/maintenance of stemness characters and tumorigenicity of glioma initiating cells.
Based on the poor survival observed in OPN-high GBM patients, ULg’s researchers explored the consequence of OPN depletion on the survival of GBM cells after irradiation. They demonstrated that the inhibition of OPN in GBM cells impaired the activation of early signal transducers of DNA double-strand damage following ionizing radiation thus resulting in an enhanced radiosensitivity of GBM cells.
This discovery identifies OPN inhibition as a therapeutic target to counteract GBM radioresistance.
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by