During movement, chondrocytes are subjected to tensile stress resulting from the sliding of articular surfaces. The Flexercell® FX4000™ is a computer-regulated bioreactor that uses vacuum pressure to apply cyclic or static strain to cells, cultured on flexible-bottomed culture plates. The force exerted on the chondrocytes and its frequency can be modulated. This model allows the study of traction on the metabolism of chondrocytes. It helps to study the effects of mechanical forces of various intensities and frequencies on the phenotype of adherent cultured cells. Moreover, different types of forces (tension, shear stress, compression) can be applied in 2D or 3D models.
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