Although dedifferentiation is a phenomenon described for decades, molecular events underlying the process are not yet fully elucidated. As a consequence, dedifferentiation still constitutes a major brake in vitro for chondrocytes expansion, thereby preventing cartilage regeneration using expanded autologous chondrocytes.
To provide better understanding of chondrocytes biology, the researchers at GIGA applied human osteoarthritis hip chondrocytes cultured in monolayer in a short-term dedifferentiation model (during 14 days). In this model, molecular events as well as substances able to delay or reverse dedifferentiation process can be tested.
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