Drug-induced toxic valvulopathy rabbit model

This model is unique given the oral instead of parenteral administration of the toxic agent.

We have demonstrated, for the first time that high dose long-term oral administration of serotonin can lead to valvular heart disease in rabbits. The tricuspid valve was commonly affected with moderate-to-severe regurgitation in all serotonin treated rabbits. The left-sided valves were less frequently and severely involved in the disease process.

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