This model is unique given the oral instead of parenteral administration of the toxic agent.

We have demonstrated, for the first time that high dose long-term oral administration of serotonin can lead to valvular heart disease in rabbits. The tricuspid valve was commonly affected with moderate-to-severe regurgitation in all serotonin treated rabbits. The left-sided valves were less frequently and severely involved in the disease process.

Contact [] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.