Electrophysiology aims at a better understanding of the role of various types of ionic channels in the modulation of neuronal activity. More particularly, it helps to:
- Evaluate the role of various ionic channels (SK K+ channels, M type K+ channels, voltage gated Na+, K+ and Ca²+ channels) in the control of the excitability of mesencephalic monoaminergic neurons;
- Better understand the biophysical properties of the proteins making up these channels
- Discover new selective modulators of these channels, able to cross the blood-brain barrier, with the hope to design future interesting central nervous system medications
Recordings are usually performed in anaesthetized animals but recordings in awake animals are presently developed. A comparison between wild-type animals and transgenic animals is also possible.
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