Electrophysiology aims at a better understanding of the role of various types of ionic channels in the modulation of neuronal activity. More particularly, it helps to:

• Evaluate the role of various ionic channels (SK K⁺ channels, M type K⁺ channels, voltage gated Na⁺, K⁺ and Ca²⁺ channels) in the control of the excitability of mesencephalic monoaminergic neurons;
• Better understand the biophysical properties of the proteins making up these channels
• Discover new selective modulators of these channels, able to cross the blood-brain barrier, with the hope to design future interesting central nervous system medications

Recordings are usually performed in anaesthetized animals but recordings in awake animals are presently developed. A comparison between wild-type animals and transgenic animals is also possible.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.