Most mouse models of graft-versus-host disease (GvHD) involve the transplantation of T-cell-depleted bone marrow supplemented with varying numbers and phenotypic classes of donor lymphocytes (either splenocytes or lymph node T-cells) into lethally irradiated recipients. The bone marrow provides donor stem cells that allow hematopoietic reconstitution after transplant. T-cell depletion is carried out to control the dose and type of immune cells that are delivered.

GvHD mouse models are used to mimic the clinical disorders of acute and chronic GvHD that occur after allogeneic bone marrow transplantation. They can also be used to study T-cell regulation, tolerance induction, autoimmune diseases and drugs or cell therapy products.

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