This model of osteoarthritic subchondral bone osteoblasts allows the comparison of the sclerotic and non-sclerotic osteoblast responses to biochemical or mechanical stimuli. Furthermore, this model can be used in an original co-culture model, in which subchondral osteoblasts in monolayer are cultured together with osteoarthritis chondrocytes in alginate beads. It’s a useful tool to evaluate potential new drugs aimed at decreasing bone sclerosis and normalizing the osteoblastic phenotype.
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