In this model, human cancer cells are transplanted either heterotopically (into the subcutaneous flank) or orthotopically (direct implantation to the mouse organ from which the tumor is originated) into immunocompromised mice.
The response to appropriate therapeutic regimes (such as anti-angiogenic drugs) on tumor size (diameter, area or volume) and animal survival (determined at regular intervals) can be pursued.
The in vivo imaging system (Xenogen®) can be used to better follow tumor progression. For more information, click here.
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