EFHC1 in juvenile myoclonic epilepsy

Mutations in the EFHC1 gene have been found in several patients suffering from juvenile myoclonic epilepsy (JME). Researchers at GIGA have shown that EFHC1 loss of function disrupts cell division and induces apoptosis in cell culture.

Using ex vivo electroporation, they observed a dramatic decrease of radial migration because both division of cortical progenitors and locomotion of postmitotic neurons are impaired in the absence of the protein. Therefore, they propose that abnormal neuronal migration during development could lead to abnormal brain circuitry that, in turn, will produce JME.

Their goal is now to study the effect of EFHC1 and of its mutated forms on neocortical development and, subsequently, to study the functional consequences of the migratory deficits induced by EFHC1 loss of function.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Related articles

PDC*line Pharma is GMP accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for its Quality Control and Release Activities for PDC*lung, a drug for lung cancer immunotherapy

Liège (Belgium), 21st January 2019. PDC*line Pharma is delighted to announce, that the company is now accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for the Quality Control and Release activities of its anticancer agent PDC*lung, intended for the treatment of patients with lung cancer.  PDC*line Pharma is developing a new

Read more
PDC*line Pharma is GMP accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for its Quality Control and Release Activities for PDC*lung, a drug for lung cancer immunotherapy

First Congress in Health Simulation

The Medical Simulation Center of the University of Liège organizes its first congress in Health Simulation: “Towards evidence-based simulation”. Event will be held on Thursday, March 28th, 2019 in the faculty of medicine amphitheatres of Liège University, located on Sart-Tilman campus. Several themes will be discussed: Evidence-based Innovations and advances in simulation Medical education –

Read more
First Congress in Health Simulation

New University Certificate for clinical trials

The Clinical Sciences Department of the Medicine Faculty of the University of Liège organizes from the academic year 2018-2019 a University Certificate in clinical trials. More information is available in this folder

Read more
New University Certificate for clinical trials