Osteoarthritis rabbit model

Osteoarthritis (OA) is a slowly progressing, degenerative disorder of synovial joints culminating in the irreversible destruction of articular cartilage and subchondral bone.

Acute anterior crucial ligament (ACL) injury has been shown to be a significant risk factor for the development of secondary OA.

In this model, OA is surgically induced by the transection of the ACL and offers herewith the opportunity to study the contributing factors (such as joint instability, changes in kinematics, and tissue degradative pathways) in the pathogenesis of OA following injury.

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