Typically, the cochlear effects of ototoxic drugs are studied in the guinea pig, which is the most common animal model used in hearing research.
In this model, guinea pigs receive an intrapritoneal injection of either Knamycin during 7 days or Cisplatin during 10 days.
Cisplatin- and aminoglycoside-induced ototoxicity is known to be mediated via injury to several terminally differentiated cellular targets in the cochlea, including the marginal and intermediate cells of the stria vascular.
To quantitatively assess hearing loss in toxic drug-treated animals, the Auditory Brainstem Responses (ABR) are measured weekly.
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