“Tumor graft models” (also known as Patient-Derived Xenografts or PDXs) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse.

To accomplish this, patient tumors must be obtained fresh from surgery. Tumors can be engrafted heterotopically or orthotopically.

PDX models may be superior to traditional cell line – xenograft models of cancer because they maintain more similarities to the parental tumors. Detailed examination of PDX mice indicate that histology and gene expression profiles are retained, along with SNPs and copy number variants.

PDX models are maintained by passaging cells directly from mouse to mouse once the tumor burden becomes too high.

PDX models offer a powerful tool for studying tumor biology and for evaluating anticancer drugs.

The in vivo imaging system (Xenogen®) can be used to better follow tumor progression. For more information, click here.

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