pilocarpine mouse model

The main features of temporal lobe epilepsy (TLE) are:

  • Epileptic foci in the limbic system
  • An “initial precipitating injury”
  • The so-called “latent period”
  • The presence of hippocampal sclerosis leading to reorganization of neuronal networks

Many of these characteristics can be reproduced in rodents by systemic injection of pilocarpine.

In this animal model, status epilepticus is followed by a latent period and later by the appearance of spontaneous recurrent seizures.

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