Protein misfolding & aggregation

Researchers at CIP use a multi-angle approach to investigate mechanisms by which soluble amyloidogenic proteins (including: human lysozyme, alpha-synuclein and polyglutamine proteins) assemble into amyloid fibrils.

Their original approach to identify and characterize these proteins in terms of structure, stability, kinetic of formation and toxicity involves:

  • The generation of heavy-chain antibody fragments (also referred as Nanobodies) specific of the amyloidogenic proteins that can be used (i) as structural probes and (ii) as potential inhibitor of the aggregation process
  • The creation of chimeric proteins composed of the beta-lactamase BlaP and amyloidogenic peptides to investigate the role of the amyloid stretches in the process of aggregation and to generate antibodies against specific amyloidogenic peptides

Interested in these projects? Drop us an email []. We are looking forward collaborating with you!

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