Researchers at GIGA have demonstrated that mammalian hair cells can be directly generated from supporting cells by inhibition of ephrin-B2 signaling.
Using either ephrin-B2 conditional knockout mice, shRNA-mediated gene silencing or soluble inhibitors, they found that downregulation of ephrin-B2 signalling at embryonic stages results in supporting cell translocation into hair cell layers and subsequent switch in cell phenotype from supporting cell to hair cell.
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