Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the brain and spinal cord. The cause of multiple sclerosis is unknown. It’s considered an autoimmune disease whereby the immune system malfunction destroys myelin. Among others, one strategy to treat MS is to stimulate the recruitment and the activation of resident oligodendrocyte precursor cells (OPCs) to differentiate them into functional myelinating cells.

In this context, researchers at GIGA are studying the role of the Elongator complex in the adult CNS demyelination and demyelination processes.

Their preliminary obtained results suggest that Elongator could play a role in the differentiation of OPCs and act as a negative regulator of the demyelination.

Interested in these projects? Drop us an email []. We are looking forward collaborating with you!