Glucocorticoids (GC) are potent anti-inflammatory drugs widely used to induce remission in rheumatoid arthritis or to treat an acute flair-up in osteoarthritis.
Unfortunately, GC contribute to adverse events giving rise to metabolic syndromes such as diabetes and weight gain, leading sometimes to a high morbidity. Accordingly, we focus on new molecules, namely selective glucocorticoid receptor agonists (SEGRAs), with a better benefit/risk ratio compared to GC. Anti-inflammatory and anti-metabolic properties of SEGRAs are evaluated in vitro on human joint cells.
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