This guinea pig model mirrors the histopathological characteristics observed in human disease. The joint pathology in both guinea pig and human is age-related and linked to a diversity of risk factors such as body weight, mechanical load and high bone turnover. It is characterized by an early collagen fibril disruption occurring in articular cartilage, bone cysts, subchondral bone thickening and osteophytes are preceding histological proteoglycan loss and fibrillation.

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