Thy1-aSyn transgenic mice

This mouse model over-expresses full-length, human, wild-type alpha-synuclein under the Thy-1 promoter.

It has been shown to reproduce many features of sporadic Parkinson Disease (PD), including progressive changes in dopamine release and striatal content, alpha-synuclein pathology, deficits in motor and non-motor functions that are affected in pre-manifest and manifest phases of PD, inflammation and biochemical and molecular changes similar to those observed in PD.

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