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State-of-the art ophthalmology platform equipment at the LBTD
In the context of a FEDER project in the GIGA, the team of Prof. Agnès Noel (LBTD-GIGA-Cancer) in collaboration with Dr. Patrice Filée (CER Marloie), Dr. Pascal de Tullio (CIRM), Prof. Jean-Marie Rakic and Dr. Vincent Lambert (Ophthalmology of CHU Liège), has acquired a state-of-the art ophthalmology platform equipment Micron IV from Phoenix Research Labs, unique in Europe.
This system allows to perform complete retinal analyses, including eye funduscopy, fluorescence angiography, Optical Coherence Tomography (OCT) and electroretinography (ERG).
It will be used to characterize therapeutic antibodies produced against a newly identified molecule involved in the progression of Age-related Macular Degeneration (AMD), which remains a major cause of blindness in people over 65 years of age.
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by