Tissue microdissection or laser capture microdissection (LCM) is an automated sample preparation technique enabling the isolation of specific cells from heterogeneous materials under microscopic visualization. LCM is contact-free, thanks to the specimen collection by gravity, which helps to minimize contamination. This precise technique allows the selective analysis of specific regions, down to single cells and the extraction of their proteins and nucleic acids.
LCM allows to obtain answers in a single cell that may otherwise have been missed in a whole tissue scrape that contains a heterogeneous mixture of healthy, stromal and cancer cells. This technique of isolating a pure sample from a heterogeneous mixture allows more efficient and accurate results with downstream microgenomics applications such as next-generation sequencing, Sanger sequencing, PCR and proteomics.
Our specific equipment includes a LDM 7000 LEICA.
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