Systematic reviews and meta-analyses are key elements of Evidence Based Medicine and Evidence Based Health Care. We have a strong experience in the design and the methodology of systematic reviews and meta-analyses. We use explicit and transparent methods following a standard set of stages and our results are accountable, replicable and updatable. We use the PRISMA statement, which is an Evidence Based minimum set of items for reporting in systematic reviews and meta-analyses. We also use the AMSTAR check list to check the methodological quality of our systematic reviews.