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The CIRM (ULg) develops innovative formulation for vaginal delivery of siRNA
Topical vaginal sustained delivery of siRNA presents a significant challenge due to the poor stability of the current formulations.
To overcome this problem, researchers at ULg (Brigitte Evrard’s Laboratory, CIRM) have developed a novel drug delivery system capable to adhere to the vaginal mucosa. The new polymeric solid mucoadhesive system was designed as such that rehydration occurs in situ by the vaginal fluids to form a hydrogel. This technology allows to deliver, in a sustained manner, mucopenetrating pegylated lipoplexes releasing the siRNA to the vaginal tissues.
To minimize adhesive interactions with vaginal mucus components, lipoplexes were coated with derivatives of polyethylene glycol (DSPE-PEG2000) and incorporated in hydroxyethyl cellulose (HEC) hydrogels. In order to avoid drug degradation and to obtain a solid and easy to handle system, the hydrogels containing pegylated lipoplexes were freeze-dried.
Frequency of application is reduced by combining muco-adhesion and prolonged drug delivery resulting in an increased patient compliance.
Liège (Belgium), 21st January 2019. PDC*line Pharma is delighted to announce, that the company is now accredited by the Belgian Federal Agency for Medicines and Health Products (FAMHP) for the Quality Control and Release activities of its anticancer agent PDC*lung, intended for the treatment of patients with lung cancer. PDC*line Pharma is developing a new
The Medical Simulation Center of the University of Liège organizes its first congress in Health Simulation: “Towards evidence-based simulation”. Event will be held on Thursday, March 28th, 2019 in the faculty of medicine amphitheatres of Liège University, located on Sart-Tilman campus. Several themes will be discussed: Evidence-based Innovations and advances in simulation Medical education –
The Clinical Sciences Department of the Medicine Faculty of the University of Liège organizes from the academic year 2018-2019 a University Certificate in clinical trials. More information is available in this folder