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The CIRM (ULg) develops innovative formulation for vaginal delivery of siRNA
Topical vaginal sustained delivery of siRNA presents a significant challenge due to the poor stability of the current formulations.
To overcome this problem, researchers at ULg (Brigitte Evrard’s Laboratory, CIRM) have developed a novel drug delivery system capable to adhere to the vaginal mucosa. The new polymeric solid mucoadhesive system was designed as such that rehydration occurs in situ by the vaginal fluids to form a hydrogel. This technology allows to deliver, in a sustained manner, mucopenetrating pegylated lipoplexes releasing the siRNA to the vaginal tissues.
To minimize adhesive interactions with vaginal mucus components, lipoplexes were coated with derivatives of polyethylene glycol (DSPE-PEG2000) and incorporated in hydroxyethyl cellulose (HEC) hydrogels. In order to avoid drug degradation and to obtain a solid and easy to handle system, the hydrogels containing pegylated lipoplexes were freeze-dried.
Frequency of application is reduced by combining muco-adhesion and prolonged drug delivery resulting in an increased patient compliance.
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by