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The University of Liège receives funding from the Interreg V-A programme (Greater Region) for the development of new bioMaterials for PROliferation and in vitro Expansion of STEM cells (Improve-Stem)
The Laboratory of Chemical Engineering (Pr. D. TOYE) and the Interfaculty Center for Biomaterials (C. GRANDFILS) from the University of Liège together with the University of Kaiserslautern, the Luxembourg Institute of Science and Technology (LIST), the Leibniz Institute for New Materials (INM), the University of Lorraine and the National Center for Scientific Research (CNRS) bring up keys competencies in materials sciences, bioprocess engineering and cell biology.
At the level of the Greater Region, this multidisciplinary consortium provides a solid basis for a platform of excellence in the field of mesenchymal stem cells culture.
Human Mesenchymal Stem Cells are multipotent cells, self-renewable, easily accessible and culturally expandable in vitro with exceptional genomic stability and few ethical issues, marking its importance in cell therapy, regenerative medicine and tissue repairmen (1). However, one of the main limiting steps in their clinical use is the amplification step.
MSC expansion on microcarriers has emerged during the last few years, fulfilling the lack of classical T-flasks expansion.
The aim of the project Improve-Stem is to develop new microcarriers with optimized surface design allowing the control of cell adhesion alongside to the design of an adapted bioreactor with operating conditions adjusted for stem cell culture on microcarriers.
About INTERREG V-A programme
The INTERREG V-A programme in the Greater Region aims at intensifying cross-border cooperation. This goal is to be achieved by means of local and regional projects between partners from the various areas in the Greater Region.
This programme is cofounded by European Union (Fonds Européen de Développement Régional)
1.Horwitz E.M., Le Blanc K., Dominici M., Mueller I., Slaper-Cortenbach I., Marini F.C., Deans R.J., Krause D.S., Keating A. International Society for Cellular Therapy. Clarification of the nomenclature for MSC: The International Society for Cellular Therapy position statement. Cytotherapy. 2005;7:393–395. doi: 10.1080/14653240500319234
In collaboration with a team at the University of California at Los Angeles (UCLA), researchers from GIGA-Neurosciences have discovered a new gene responsible for a seizure syndrome called juvenile myoclonic epilepsy (JME). This discovery was made as part of an international consortium that studies genetic abnormalities responsible for epileptic diseases. It is being published this week in
The LIGHTSHEET MICROSCOPY can deliver optical sections, 3D reconstructions and timelapse movies of whole sample volumes at subcellular resolutions. The fast scan speeds and low phototoxicity of the lightsheet allow to record the development of fluorescent transgenic animals over long time periods, such as zebrafish embryos. Alternatively 3D reconstructions of fixed whole organs or whole embryos,
The researchers discovered that this cellular dialogue controls the growth of the cerebral cortex and that its impairment leads a cortical malformation previously associated with autism in mice . Their results are published in the prestigious scientific journal Cell. The cerebral cortex contains excitatory and inhibitory interneurons. The former are produced locally and move by