Thrombotic diseases

Clinical management of cardiovascular thrombotic diseases and participation in several international studies in acute coronary syndromes.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Cardio-oncology

At Belgian level, CHU de Liège coordinates the European multicenter registry which is in charge to evaluate current practices in terms of diagnosis and management of cardiac toxicity of breast cancer treatments (COT registry: EACVI/HFA Cardiac Oncology Toxicity Registry in Breast Cancer: EURObservational Research Program of the European Society of Cardiology).

In addition, our team evaluates new cardiac toxicity biomarkers (mRNA, BNP, ST2, Troponine, etc) in breast cancer as well as multi-modality imaging evaluations of cardiovascular complications of radiotherapy in adult.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

 

Valvular Heart Disease

Our team has been working for 10 years on valvular heart disease and highlighted several factors of poor clinical outcome through biomarker assay  (BNP, ST2, etc), the use of advanced echocardiographic techniques (study of myocardial deformation, ultrasound effort, etc) and the assessment of functional capacity.

CHU de Liège has created the ‘Heart Valve Clinic’, regrouping a multidisciplinary team of cardiologists, nurses, radiologists, anaesthesiologists and surgeons:

  • Proficient in diagnosing and treating all cardiac valve syndromes and disorders. This involves sophisticated cardiac valve symptoms recognition, diagnostic techniques such as three-dimensional echocardiography, cardiac magnetic resonance, cardiac CT and cardiac catheterization
  • Providing help in optimizing and monitoring medical treatment
  • Assisting the general cardiologists for clinical decision-making
  • Determining the correct timing and type of intervention
  • Referring the patient to the most suitable surgeon
  • Assessing results after intervention
  • Informing patients to motivate them to follow their prescribed medications and be alert for signs indicating a worsening of their disease

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Abdominal aortic aneurysms

A study carried out by the teams at CHU de Liège revealed that recourse to the PET-CT medical imaging method was efficient in detecting aneurysms that are likely to rupture.

They are currently exploring if a correlation between PET-CT images and the presence of specific molecules in the samples of aortic wall taken from the areas of high metabolic activity in the aneurysm can be detected.

With the collaboration of the Karolinska Institute, the CHU de Liège has launched a systematic screening campaign for abdominal aortic aneurysm, which is funded by Aneurysmal Pathology Foundation (APF).

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Clinical imaging capabilities

Together, the CHU and the GIGA have a vast expertise in clinical imaging techniques, individually or combined in a multimodal functional imaging approach.

  • Use of specific phenotypes in NMR imaging as risk markers in cardiovascular lesions
  • Development of specific contrast agents for unstable atherosclerotic lesions

Angiography relies on the introduction of a radio-opaque contrast agent allowing to use X-ray based techniques to visualize the inside of blood vessels (arteries, veins and the heart chambers).

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Echocardiography creates ultrasound images of heart structures providing information on the heart size and shape (internal chamber size quantification), pumping capacity and the location and extent of any tissue damage. It also gives other estimates of heart function such as a calculation of the cardiac output, ejection fraction, and diastolic function and helps to detect blood clots, fluid buildup and problems with the aorta.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

ECG is a commonly used, non invasive procedure for recording electrical changes in the heart.

It is the basic measurement used in exercise tolerance tests (i.e., stress tests) and symptoms evaluation such as chest pain, shortness of breath, and palpitations.

In addition, we also perform signal-averaged electrocardiographies, a computerized technique detecting subtle abnormalities in the surface electrocardiogram. Multiple electric signals from the heart are averaged to remove interference and reveal small variations in the late potentials.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Picture3

Magnetic resonance imaging (MRI) scanners use strong magnetic fields and radio-waves to visualize detailed-internal structures. Images are obtained in vivo with very high spatial and temporal resolution and good contrast for brain and soft tissues. MRI can be used in a wide variety of applications including anatomical, functional (fMRI) and molecular imaging for medical diagnosis, staging of disease and for follow-up without exposure to ionizing radiation.

Equipment: two 3T Siemens Allegra with parallel imaging capabilities (8-channel receive coil), one 1.5T Siemens Symphony and two 1.5 Siemens Aera Scanners.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Cardiac magnetic resonance imaging (CMR) is a medical imaging technology for the non-invasive assessment of the function and structure of the cardiovascular system. It is derived from and based on the same basic principles as magnetic resonance imaging (MRI) but with optimization for use in the cardiovascular system. These optimizations are principally in the use of ECG gating and rapid imaging techniques or sequences.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

gemini tf16Positron Emission Tomography (PET) has the sensitivity to visualize at picomolar level molecular processes in 3D and in a volume and target-depth independent manner. As a stand-alone device or combined with a CT scanner (PET-CT), it allows a wide range of clinical and experimental applications:

  • Dynamic brain imaging (arterial blood sampling):
    • Concentration analysis of targeted analytes
    • Dynamic PET with tracer kinetic modeling techniques
  • Static brain imaging with 18F radiopharmaceuticals
  • Whole-body imaging for dosimetry:
    • Collection of quantitative and dynamic biodistribution data
    • Detailed drug occupancy studies
  • Whole-body imaging for metabolic evaluation, receptor or gene expression, with or without full diagnostic contrast-enhanced CT imaging

Equipment: PET scanner Siemens HR+, PET/CT Philips Gemini TF16 & Philips Gemini TF Big Bore (fully fitted for RT Planning)

In addition, we have:

  • Expertise in the development of new radioligand (for more info, click here)
  • Marketing Authorization Application to produce 18F-FDG (#BE241132)
  • Marketing Authorization Application to produce 68GA labelled compound
  • Certification to synthesize radiolabeled registered and experimental drugs
  • Authorization to conduct research programs with clinically validated 18F-FDG or original radiotracers
  • Expertise in experimental design, data collection, correction and modeling for kinetic analysis

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Picture4

SPECT is a nuclear medicine tomographic imaging technique, which uses radiopharmaceutical emitting gamma rays. Similar to PET, it can be combined with a computed tomography (CT), a cross-sectional technique that yields structural and anatomical high-resolution 3D images.

Equipment: 2 SPECT-CT Siemens Symbia T6, 1 SPECT Siemens E-Cam.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

BrightSpeedElite-281x300A computerized tomography (CT) scan combines a series of X-ray images taken from different angles and uses computer processing to create cross-sectional images, or slices, of bones, blood vessels and soft tissues inside the body.

Equipment: 2 GE Brightspeed Elite scanners, 2 Siemens Somaton Emotion scanners, 1 Siemens Somaton Definition scanner.

Ergospirometry is a diagnostic procedure to continuously measure respiration and gas metabolism during ergometer exercise. It enables judgement of function and performance capacity of the cardiopulmonary system and metabolism while performing quantified physical work.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].