Stability testing
Stability testing is performed after storage in defined conditions according to standard and accelerated ICH conditions. We provide you with different range of storage conditions. All storage rooms are fully-controlled with 24/7 monitoring and alert systems. Our services include: Support in designing studies for real-time Development and validation of “stability indicating methods” Examination of stability-relevant […]
Protein misfolding & aggregation
Researchers at CIP use a multi-angle approach to investigate mechanisms by which soluble amyloidogenic proteins (including: human lysozyme, alpha-synuclein and polyglutamine proteins) assemble into amyloid fibrils. Their original approach to identify and characterize these proteins in terms of structure, stability, kinetic of formation and toxicity involves: The generation of heavy-chain antibody fragments (also referred as Nanobodies) specific of […]
AMPA potentiators
The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA […]
Thiamine & neuronal death prevention
Researchers at GIGA have a large expertise in the analysis of thiamine compounds. Few years ago, they have discovered a new thiamine derivative: the adenosine thiamine triphosphate. Their current research focuses on the use of thiamine and its precursors as therapeutic agents in neurodegenerative diseases due to their high bioavailability. More particularly, they aim at identifying the pharmacologically […]
Potassium channel modulators
The new compounds based on disubstituted anilines, by opening potassium channels, can be used for the treatment of vasospastic disorders (i.e. subarachnoid hemorrhage and migraine), of various diseases of the central nervous system (i.e. epilepsy, ischemia and neurodegenerative diseases) as well as pain treatment. Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward […]
Calcium-activated potassium channel modulators
Small conductance calcium-activated potassium (SK, KCa2) channels represent interesting and challenging targets in medicinal chemistry. So far, the reference ligand is apamin, a peptide including the [125I] analog for binding studies. Nonpeptidic ligands with high affinity have been developed for several years. Currently, different questions remain to be solved since no selective and brain-penetrating agent […]
Drug administration & Patient monitoring
Centralized clinical unit with 30 equipped hospital beds Experience in running different study types and trial design Different types of drugs like NCE and NBE Database of more than 2.700 healthy and reliable volunteers Privileged access to medical and technical expertise of CHU and ULg (such as Cyclotron, GIGA, CIP, Sleep Center, Pain clinic…) We offer […]
Induced pluripotent stem cells
Due to the close association with the CHU de Liège, GIGA researchers have access to fibroblasts of patients. They have developed a large expertise in the generation of induced pluripotent stem cells, their characterization and differentiation into specialized neuronal cells in vitro. Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you […]
Stem Cells
Teams at GIGA are specialized in the investigations of stem cells (including mesenchymal stem cells and neural crest stem cells) biology, purification and expansion, as well as in their therapeutic use in the context of regenerative medicine. Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.
Novel pharmaceutical formulations
Researchers at ULg have a broad expertise in the development of novel pharmaceutical formulations to improve the solubility and the bioavailability of compounds and to facilitate drug delivery to brain cells. To test these new formulations, they have also developed a cellular blood brain barrier model using immortalized human cerebral microvascular endothelial cells. For more […]