New TP receptor antagonists

Researchers at CIRM have synthesized and evaluated new series of original 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as thromboxane A2 receptor (TP receptor) antagonists.

Based on functional pharmacological test, several compounds were found to be as potent as the 2-arylamino-5-nitrobenzenesulfonylurea reference compound BM-573, supporting the view that the bio-isosteric replacement of the nitro group by a cyano group was tolerated.

TP receptor antagonist activity of the most promising molecules was confirmed in a platelet aggregation assay using the TP receptor agonist U-46619 as a pro-aggregant.

Three compounds were identified as leads for further non-clinical pharmacological and toxicological studies.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Cardiac Markers

We study new necrosis and fibrosis cardiac biomarkers in athletes to show their specificity as well as to highlight a cardiac biomarker helpful to discover potential risk of cardiac event during exercise.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Stability testing

Stability testing is performed after storage in defined conditions according to standard and accelerated ICH conditions. We provide you with different range of storage conditions. All storage rooms are fully-controlled with 24/7 monitoring and alert systems.

Our services include:

  • Support in designing studies for real-time
  • Development and validation of “stability indicating methods”
  • Examination of stability-relevant parameters (temperature – humidity)
  • Interim reports for every testing period
  • Comprehensive final report

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Thrombotic diseases

Clinical management of cardiovascular thrombotic diseases and participation in several international studies in acute coronary syndromes.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Cardio-oncology

At Belgian level, CHU de Liège coordinates the European multicenter registry which is in charge to evaluate current practices in terms of diagnosis and management of cardiac toxicity of breast cancer treatments (COT registry: EACVI/HFA Cardiac Oncology Toxicity Registry in Breast Cancer: EURObservational Research Program of the European Society of Cardiology).

In addition, our team evaluates new cardiac toxicity biomarkers (mRNA, BNP, ST2, Troponine, etc) in breast cancer as well as multi-modality imaging evaluations of cardiovascular complications of radiotherapy in adult.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

 

Valvular Heart Disease

Our team has been working for 10 years on valvular heart disease and highlighted several factors of poor clinical outcome through biomarker assay  (BNP, ST2, etc), the use of advanced echocardiographic techniques (study of myocardial deformation, ultrasound effort, etc) and the assessment of functional capacity.

CHU de Liège has created the ‘Heart Valve Clinic’, regrouping a multidisciplinary team of cardiologists, nurses, radiologists, anaesthesiologists and surgeons:

  • Proficient in diagnosing and treating all cardiac valve syndromes and disorders. This involves sophisticated cardiac valve symptoms recognition, diagnostic techniques such as three-dimensional echocardiography, cardiac magnetic resonance, cardiac CT and cardiac catheterization
  • Providing help in optimizing and monitoring medical treatment
  • Assisting the general cardiologists for clinical decision-making
  • Determining the correct timing and type of intervention
  • Referring the patient to the most suitable surgeon
  • Assessing results after intervention
  • Informing patients to motivate them to follow their prescribed medications and be alert for signs indicating a worsening of their disease

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

P2X1 transgenic mice

We have generated transgenic mice overexpressing the human P2X1 ion channel in the megakaryocytic cell lineage. Platelets from transgenic mice exhibited a gain of P2X1 ionotropic activity as determined by more prominent P2X1– mediated Ca2+ influx and platelet shape change.

P2X1 overexpression enhanced platelet secretion and aggregation evoked by collagen, convulxin, a GPVI-selective agonist, or the thromboxane A2 mimetic U46619.

In contrast, these platelet responses to ADP and thrombin were normal.

Hence, the platelet P2X1 ion channel plays a role in hemostasis and thrombosis through its participation in collagen-, thromboxane A2 and shear stress-triggered platelet responses. Activation of the ERK2 pathway is instrumental in these processes.

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Abdominal aortic aneurysms

A study carried out by the teams at CHU de Liège revealed that recourse to the PET-CT medical imaging method was efficient in detecting aneurysms that are likely to rupture.

They are currently exploring if a correlation between PET-CT images and the presence of specific molecules in the samples of aortic wall taken from the areas of high metabolic activity in the aneurysm can be detected.

With the collaboration of the Karolinska Institute, the CHU de Liège has launched a systematic screening campaign for abdominal aortic aneurysm, which is funded by Aneurysmal Pathology Foundation (APF).

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Abdominal aortic aneurysm

Teams at the CHU hospital and the ULg are on the trail of markers that can predict the instability of abdominal aneurysms.

They examined, among other things, the proteins in the extracellular matrix of the aortic walls and shown a correlation between the instability of an aneurysm and the presence of MMP-9 and -2, enzymes that participate in the deterioration of elastin and collagens.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

New mechanisms of Platelet activation

In order to identify new mechanisms or candidate genes involved in platelet biology, our team generated a cohort of healthy individuals.

A genome-wide association study is ongoing to identify genetic loci associated with platelet reactivity.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!