Stability testing

Stability testing is performed after storage in defined conditions according to standard and accelerated ICH conditions. We provide you with different range of storage conditions. All storage rooms are fully-controlled with 24/7 monitoring and alert systems.

Our services include:

  • Support in designing studies for real-time
  • Development and validation of “stability indicating methods”
  • Examination of stability-relevant parameters (temperature – humidity)
  • Interim reports for every testing period
  • Comprehensive final report

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Drug administration & Patient monitoring

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  • Centralized clinical unit with 30 equipped hospital beds
  • Experience in running different study types and trial design
  • Different types of drugs like NCE and NBE
  • Database of more than 2.700 healthy and reliable volunteers
  • Privileged access to medical and technical expertise of CHU and ULg (such as Cyclotron, GIGA, CIP, Sleep Center, Pain clinic…)

We offer you a professional and scientific support to conduct clinical trials and the decision making processes during the early phases of the development of new molecules. This includes clinical pharmacology trials giving an insight into a drug candidate’s safety, tolerability, pharmacokinetics and pharmacodynamics.

Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].


Bird Models

These models are used to identify the neuroendocrine and neurochemical mechanisms involved in the activation and the sexual differentiation of the brain and reproductive behaviors:

  • Quail and song bird models of endocrine control of sex differences and of the sexual differentation of brain and behavior
  • Quail models of control of reproductive behaviors by steroids and catecholamines
  • Bird models of role of steroids on brain morphology and behavior
  • Song bird models of control by steroid and the impact of social environment on brain plasticity

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Transgenic mouse models

To study the sexual differentiation of brain and analyze the neural circuits underlying reproduction, including behavior, researchers at GIGA use different transgenic mouse models such as:

  • Aromatase knock-out (ArKO) mouse model to study the role of oestradiol in the development of female brain
  • Kiss-KO mice: targeted mutation in the Kiss1 gene to study the role of kisspeptin in reproductive physiology and behavior
  • nNOS-KO mice: targeted mutation in the gene encoding the neuronal form of the nitric oxide synthase enzyme, which is important for the production of the gazeous neurotransmitter nitric oxide (NO). This model is also used to study the role of NO in reproductive physiology and behavior
  • Kiss-Cre mice and GnRH-Cre mice: to specifically delete (by viral ablation for example) or stimulate by optogenetics kisspeptin or GnRH neurons and then determine their effects on reproductive physiology and behavior

Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We will help you develop tailored solutions.

Neuroanatomical and histochemical studies

Neuroanatomical and histochemical studies are performed on brain tissues, postmortem analyses of patient with disorders of sexual differentiation (DSD) or suffering from gender dysphoria (GD).

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Neuroendocrine and neurochemical mechanisms

We have investigated the neuroendocrine and neurochemical mechanisms involved in the activation and the sexual differentiation of the brain, reproductive behaviors and the onset of puberty. More specifically, we have analyzed the impact of endocrine disruptor chemicals (EDC) on puberty onset and hippocampal neurogenesis.

Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Bio-analysis

  • Standard biology analysis: certification for more than 550 tests, 17025 and 15189 ISO standards and BELAC accreditation
  • Development of personalized drug monitoring
  • Determination of IMP, metabolites and drug residues in different biological matrices
  • PK, PD and immunogenicity testing

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Looking for clinical advice or support, or preparing for a clinical study? We will help you set up a cost-effective and time-efficient study! Get in touch with our experts [info@b2h.be].

Preclinical imaging

Our GIGA platforms offer advanced preclinical functional and anatomical imaging solutions for a broad spectrum of application fields.

Our range of techniques includes: