[18F]SV2A – early diagnosis

In a transgenic mouse model, overexpressing human α–syn under the mThy1 promotor (Parkinson mouse model), researchers have proved that the new SV2A-radioligand developed at CRC is a valid biomarker to study the loss of synaptic terminals appearing before the occurrence of behavioral disturbances. Contact [info@b2h.be] us to discuss how these capabilities can forward your projects! We […]

[18F]FMT – evaluation of dopaminergic dysfunction

Researchers at CRC have evaluated the feasibility of in vivo PET study using 6-[18F]fluoro-m-tyrosine (6-[18F]FMT) on lesioned rats with 6-hydroxydopamine (6-OHDA), a rat model of Parkinson’s disease (PD). The (6-[18F]FMT) is an effective PET tracer to evaluate DA terminals integrity and L-aromatic amino acid decarboxylase (AAAD) metabolic pathway. Using this PET tracer, they were able […]

Stability testing

Stability testing is performed after storage in defined conditions according to standard and accelerated ICH conditions. We provide you with different range of storage conditions. All storage rooms are fully-controlled with 24/7 monitoring and alert systems. Our services include: Support in designing studies for real-time Development and validation of “stability indicating methods” Examination of stability-relevant […]

Protein misfolding & aggregation

Researchers at CIP use a multi-angle approach to investigate mechanisms by which soluble amyloidogenic proteins (including: human lysozyme, alpha-synuclein and polyglutamine proteins) assemble into amyloid fibrils. Their original approach to identify and characterize these proteins in terms of structure, stability, kinetic of formation and toxicity involves: The generation of heavy-chain antibody fragments (also referred as Nanobodies) specific of […]

AMPA potentiators

The AMPA subtype of glutamatergic receptors is the main actor in the excitatory neurotransmission in the mammalian central nervous system. These receptors are involved in the expression and the maintenance of the long-term potentiation, a phenomenon closely linked to cognitive and memorization processes. Based on experimental data collected in recent years, the use of AMPA […]

Thiamine & neuronal death prevention

Researchers at GIGA have a large expertise in the analysis of thiamine compounds. Few years ago, they have discovered a new thiamine derivative: the adenosine thiamine triphosphate. Their current research focuses on the use of thiamine and its precursors as therapeutic agents in neurodegenerative diseases due to their high bioavailability. More particularly, they aim at identifying the pharmacologically […]

Diagnostic biomarkers

We are looking for new diagnostic biomarkers of Parkinson’s disease from biological samples. We aimed at developing an induced pluripotent stem cell model of alpha-synuclein overexpression to test diagnostic biomarkers and new disease-modifying therapies of Parkinson’s disease. Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward collaborating with you!

Potassium channel modulators

The new compounds based on disubstituted anilines, by opening potassium channels, can be used for the treatment of vasospastic disorders (i.e. subarachnoid hemorrhage and migraine), of various diseases of the central nervous system (i.e. epilepsy, ischemia and neurodegenerative diseases) as well as pain treatment. Interested in these projects? Drop us an email [info@b2h.be]. We are looking forward […]

Calcium-activated potassium channel modulators

Small conductance calcium-activated potassium (SK, KCa2) channels represent interesting and challenging targets in medicinal chemistry. So far, the reference ligand is apamin, a peptide including the [125I] analog for binding studies. Nonpeptidic ligands with high affinity have been developed for several years. Currently, different questions remain to be solved since no selective and brain-penetrating agent […]

Drug administration & Patient monitoring

Centralized clinical unit with 30 equipped hospital beds Experience in running different study types and trial design Different types of drugs like NCE and NBE Database of more than 2.700 healthy and reliable volunteers Privileged access to medical and technical expertise of CHU and ULg (such as Cyclotron, GIGA, CIP, Sleep Center, Pain clinic…) We offer […]